Antifungal efficacy of Microrobots

 

Antifungal efficacy of Microrobots:

Small robotics, specifically mobile robots with characteristic dimensions less than 1 mm, are known as microbotics or microrobots. A microrobot is a tiny robot designed to carry out particular tasks. A microrobot is typically somewhat bigger than a nanorobot, which is made at the nanoscale. While some nanobots are not instantly apparent to the human eye, microrobots are typically visible

Current treatments (such as nanoparticles) can have a variety of negative effects and function slowly and ineffectively. In addition, the problem of growing drug resistance diseases in the field of antifungal therapy. 
Researchers at the University of Pennsylvania, Hyun (Michel) Koo and Edward Steager, joined forces with their teams in an initiative to use microrobots to target microbial coatings on soft surfaces. In an email to ASN, Koo stated, "Our study has developed a new strategy using tiny robotic particles called nanozyme microbots to fight fungal infections caused by Candida." 

These nanozyme-bots can be programmed to target the infection site precisely and destroy fungal pathogens quickly. Nanozymes are magnetic and catalytic nanoscale particles that have shown some promise in the treatment of bacterial diseases. With their ability to be controlled by magnetism and their capacity to catalyse the death of microorganisms, iron oxide nanozymes have two distinct benefits. Iron oxide nanoparticles can initiate a reaction that converts hydrogen peroxide into more harmful forms of oxygen known as reactive oxygen species, which kills fungi. This reaction is similar to the one started by the body's peroxidase enzyme and is carried out by the breakdown of hydrogen peroxide.

Koo and Steager choose to use these nanozymes to address this issue because their use as antifungals has been constrained. According to Koo, we designed a magnetic field control device and programmable algorithms that automate the targeting procedure developed in our laboratory in order to precisely and consistently treat the biofilm with nanozyme microbots. The nanozymes moved in the direction of the magnetic field, which was maintained by perpetual motion motorized devices that had been pre-programmed.

Reference: 

Edward Steager, Hyun Koo, et al., Nanozyme-based robotics approach for targeting fungal infection, Advanced Materials (2023). DOI: 10.1002/adma.202300320

https://www.advancedsciencenews.com/microrobots-kill-fungal-infections-in-just-ten-minutes/


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